Lariam (Mefloquine) is indicated for the following; Treatment of Acute Malaria Infections Lariam (mefloquine) is indicated for the treatment of mild to moderate acute malaria caused by mefloquine-susceptible strains of P. falciparum (both chloroquine-susceptible and resistant strains) or by Plasmodium vivax. There are insufficient clinical data to document the effect of mefloquine in malaria caused by P. ovale or P. malariae.
Note: Patients with acute P. vivax malaria, treated with Lariam (mefloquine) , are at high risk of relapse because Lariam (mefloquine) does not eliminate exoerythrocytic (hepatic phase) parasites. To avoid relapse, after initial treatment of the acute infection with Lariam (mefloquine) , patients should subsequently be treated with an 8-aminoquinoline derivative (eg, primaquine).
Prevention of Malaria Lariam (mefloquine) is indicated for the prophylaxis of P. falciparum and P. vivax malaria infections, including prophylaxis of chloroquine-resistant strains of P. falciparum.