The antioxidants in grape seed extract can potentially protect the blood vessels from becoming damaged, which may prevent high blood pressure. Improving bone strength - Including grape seed extract in your diet with calcium has a beneficial effect on bone formation and bone strength for the treatment of bone debility caused by a low level of calcium. Preventing skin cancer - Grape seeds contain proanthocyanidins which can prevent the development of cancer. Topical application of GSPE represents a feasible and productive approach to support dermal wound healing. Taking grape seed extract can help reduce the swelling that occurs after an injury or surgery.